Luis Medina Cantalejo is a Spanish former football referee.
He was one of the few officials allowed to officiate the domestic clashes between Real Madrid and Barcelona.
His first experience as an international referee came on 4 September 2004, between Turkey and Georgia, in a preliminary qualifier for the 2006 FIFA World Cup.
Medina was appointed as fourth official for the FIFA World Cup Final between Italy and France and was involved in another important decision during the final, as none of the three officials on the field saw Zinedine Zidane headbutting Marco Materazzi. He informed referee Horacio Elizondo what had happened via headset. The French captain was then shown the red card.