| Actor | Hiroshi Fujioka, Kirk Thornton (as Black Jack (voice)), Akio Ōtsuka (as Black Jack (voice)), Michael Sorich (as Additional Voices (voice)), Barry Stigler (as Thomas Johnston (voice)), Lex Lang (as Additional Voices (voice)), Daran Norris (as (voice)), Kevin Seymour (as Additional Voices (voice)), Michael Forest (as Roger Siegel (voice)), Simon Prescott (as Panel Host, Professor Michigan (voice)), Paul St. Peter (as Additional Voices (voice)), Tony Pope (as Additional Voices (voice)), Peter Spellos (as Mr. Brane (voice)), Dan Woren (as Nicholas Doris (voice)), Christopher Joyce (as Dr. Eric Caderry (voice)), Jan Rabson (as Son (voice)) |
| Actress | Julie Maddalena (as Pinoko (voice)), Yūko Mizutani (as Pinoko (voice)), Mary Elizabeth McGlynn (as Jo Carol Brane (voice)), Bridget Hoffman (as Ellen Shryer (voice)), BJ Harrison (as Additional Voices (voice)), Mona Marshall (as Nomad (voice)), Riva Spier (as Fendy (voice)), Wendee Lee (as Betty Moore / Lisa Siegel (voice)) |
| Animator | Keiki Kobayashi (as key animator), Akio Sugino (as character designer / key animator), Osamu Tezuka (as original character design) |
| Art Director | Jirô Kôno, Kazuo Okada, Masami Saitô |
| Cinematographer | Hirokata Takahashi |
| Director | Osamu Dezaki, Fumihiro Yoshimura |
| Executive Producer | Takayuki Matsutani, Yoshihiro Shimizu |
| Film Editor | Seiji Morita |
| Music | Eiji Kawamura, Kazuo Kumada (as music producer) |
| Producer | Minoru Kubota, Sumio Udagawa |
| Production | Layton Morrison (as stunts), Satoshi Kuwabare (as production coordinator), Akira Nagai (as medical consultant / medical supervisor), Kevin Seymour (as english voice director), Toshitaka Takeshita (as medical consultant) |
| Sound | Phil Brewster (as re-recording mixer / sound effects editor), Etsushi Yamada |
| Writer | Osamu Dezaki, Udo Lindenberg (as (story)), Eto Mori, Kihachi Okamoto, Osamu Tezuka (as (comic)), Osamu Tezuka (as (story)), Kuniaki Yamashita |
| Links | https://www.imdb.com/title/tt0106421/ |
